Dr. Bolton's research focuses on understanding how brain circuitry is altered by genetic disorders and injury. The brain is composed of hundreds of distinct types of neurons arranged in highly specialized areas with specific patterns of synaptic connections and unique intrinsic properties that determine their functionalproperties. In disorders such as Huntington's Disease, Parkinson's Disease, Alzheimer's Disease, Schizophrenia, Autism, and Epilepsy, synaptic connections and intrinsic properties of specific populations of neurons are altered leading to circuit imbalances and functional deficits. Research in Dr. Bolton's lab employs electrophysiological and imaging techniques to study alterations in circuit structure and function in mouse models of neurological and psychiatric disorders. Understanding these changes and the cellular and molecular mechanisms that underlie them holds the promise of new therapeutic advances.