Hyungbae Kwon, PhD

Hyungbae Kwon, PhD

Research Group Leader
Cellular Basis of Neural Circuit Plasticity

One Max Planck Way
Jupiter, FL 33458
(561) 972-9000

info@maxplanckflorida.org

Visit Hyungbae Kwon's Lab Website

Researcher Bio

Dr. Kwon joined the Max Planck Florida Institute for Neuroscience (MPFI) in July 2012 and heads the research group of Cellular Basis of Neural Circuit Plasticity. Before coming to MPFI, Dr. Kwon worked in the Department of Neurobiology at Harvard Medical School, where he served as a post-doctoral fellow in the laboratory of Dr. Bernardo Sabatini, a Howard Hughes Medical Institute investigator. During his postdoctoral fellowship, he used cutting-edge laser-based optics to understand mechanisms of excitatory synapse formation. Prior to working with Dr. Sabatini at Harvard Medical School, Dr. Kwon received his PhD in Dr. Pablo Castillo’s lab at the Albert Einstein College of Medicine. Dr. Kwon’s PhD thesis described the role of glutamate ionotropic receptors in short-term and long-term plasticity at the mossy fiber synapse, which provides the main excitatory input to the hippocampus proper.

Dr. Kwon graduated from Korea University earning a BS in 1997 and an MS degree in Biochemistry in 1999. He continued his research career at Yonsei University Medical Center where he examined the role of Drosophila MAP kinases and MAPK phosphatases during cell proliferation using various genetic and cell biological techniques.

Dr. Kwon is the recipient of numerous honors including The Society for Neuroscience Chapter Graduate Student Award, the Association of Korean Neuroscientists Outstanding Research Award, and the 13th Julius Marmur Research Award from the Albert Einstein College of Medicine.

Selected Publications

  1. Kwon HB, Kozorovitskiy Y, Oh, WJ, Peixoto RT, Akhtar N, Saulnier JL, Gu C, Sabatini BL., (2012) Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number. Nature Neuroscience (published online 11 Nov 2012)

  2. Mukherjee K, Yang X, Gerber SH, Kwon HB, Ho A, Castillo PE, Liu X, Südhof TC., (2010) Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis. Proc Natl Acad Sci U S A. 107(14):6504-9

  3. Peixoto RT, Kunz PA, Kwon HB, Mabb AM, Sabatini BL, Philpot BD, Ehlers, MD., (2012) Transsynaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1. Neruon 76: 396-409

  4. Kwon HB and Sabatini BL., (2011) Glutamate induces de novo growth of functional spines in developing cortex. Nature 474 (7349):100-4.

  5. Kwon HB and Castillo PE., (2008) Role of Glutamate Autoreceptors at Hippocampal Mossy Fiber Synapses. Neuron 60: 1082-1094

  6. Kaeser PS, Kwon HB, Chiu CQ, Deng L, Castillo PE, Südhof TC., (2008) RIM1α and RIM1β are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J. Neurosci., 28: 13435-13447

  7. Kaeser PS, Kwon HB, Blundell J, Chevaleyre V, Morishita W, Malenka RC, Powell CM, Castillo PE, Südhof TC., (2008) RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning. Proc Natl Acad Sci U S A. 105(38):14680-5

  8. Kwon HB and Castillo PE., (2008) Long-Term Potentiation Selectively Expressed by NMDA Receptors at Hippocampal Mossy Fiber Synapses. Neuron 57: 108-20
    * previewed by Angharad M. Kerr and Peter Jonas (2008) Neuron 57: 5-7

  9. Chandra S, Fornai F, Kwon HB, Yazdani U, Atasoy D, Liu X, Hammer RE, Battaglia G, German DC, Castillo PE, Südhof TC., (2004) Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A 101: 14966-14971

  10. Kwon HB, Kim SH, Kim SE, Jang IH, Ahn Y, Lee WJ, Choi KY., (2002) Drosophila Extracellular Signal Regulated Kinase Involves in The Insulin Mediated Proliferation of Schneider Cells. J. Biol. Chem. 277: 14853-14858

  11. Kim SH, Kwon HB, Kim YS, Ryu JH, Kim KS, Ahn Y, Lee WJ, Choi KY., (2002)Isolation and Characterization of A Drosophila Homologue of MKP-3 Which Has A High Substrate Specificity Toward ERK. Biochem. J. 361: 143-151