Dr. Ryohei Yasuda was named Scientific Director of the Max Planck Florida Institute for Neuroscience in 2012 and heads the Neuronal Signal Transduction Lab. The focus of Dr. Yasuda’s lab is to elucidate some of the molecular mechanisms underlying synaptic plasticity and ultimately learning and memory.
Dr. Yasuda received his PhD in Physics in 1998 from Keio University Graduate School of Science and Technology in Yokohama, Japan. In his PhD studies, he demonstrated that the enzyme ATP synthase is a rotary motor made of single molecule and that its energy conversion efficiency is close to 100%. From 2000 to 2005, he was a post-doctoral fellow at the Cold Spring Harbor Laboratory where he built an imaging device to monitor protein interactions in living cells with high sensitivity and resolution. From 2005 to 2012, he was an assistant professor of the Neurobiology department at the Duke University Medical Center where he developed a number of techniques to visualize signaling activity in single synapses. From 2009 to 2012, Dr. Yasuda served as an Early Career Scientist at the Howard Hughes Medical Institute.
Dr. Yasuda has received a number of awards for his research accomplishments including the Career Award at the Scientific Interface from the Burroughs Wellcome Fund, the Alfred P. Sloan Fellowship, the New Investigator Award from the Alzheimer’s Association, and Research Award for Innovative Neuroscience from the Society for Neuroscience.
M. Shibata, T. Uchihashi, T Ando, R Yasuda. Long-tip high-speed atomic force microscopy for nanometer-scale imaging in live cells Scientific Reports 5, 8724; DOI:10.1038/srep08724 (March 4 2015).
Kim IH, Wang H, Soderling SH, Yasuda R. Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall. Elife 2014 Jul 8:e02839. doi: 10.7554/eLife.02839 (2014)
A.F. Oliveira and R. Yasuda. Neurofibromin is the major ras inactivator in dendritic spines. J Neurosci. 2014 Jan 15;34(3):776-83. doi: 10.1523/JNEUROSCI.3096-13.2014. (2014)
S. Zhai, E.D. Ark, P. Parra-Bueno, R. Yasuda. Long-distance integration of nuclear ERK signaling triggered by activation of a few dendritic spines. Science. Nov 29;342(6162):1107-11. doi: 10.1126/science.1245622. (2013)
L.A. Colgan, R. Yasuda. Plasticity of Dendritic Spines: Subcompartmentalization of Signaling. Annu Rev Physiol. Nov 6. (2013)
A.F. Oliveira, R. Yasuda. Imaging the activity of Ras superfamily GTPase proteins in small subcellular compartments in neurons. Methods Mol Biol. 1071:109-28. doi: 10.1007/978-1-62703-622-1_9. (2014)
E. M. Szatmari, A.F. Oliveira, E.J. Sumner, and R. Yasuda. Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction. J Neurosci. 33(12):5367-5374. doi: 10.1523/JNEUROSCI.2641-12.2013. (2013)
H. Watanabe, T. Uchihashi, T. Kobashi, M. Shibata, J. Nishiyama, R. Yasuda, T. Ando. Wide-area scanner for high-speed atomic force microscopy. Rev Sci Instrum. May;84(5):053702. doi: 10.1063/1.4803449. (2013)
I.H. Kim, B. Racz, H. Wang, L. Burianek, R. Weinberg, R. Yasuda, W.C. Wetsel, S.H. Soderling. Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. J Neurosci. Apr 3;33(14):6081-92. doi: 10.1523/JNEUROSCI.0035-13 (2013)
A.F. Oliveira, R. Yasuda. An improved Ras sensor for highly sensitive and quantitative FRET-FLIM imaging. PLoS One. 8(1):e52874. doi: 10.1371/journal.pone.0052874. Epub 2013 Jan 14. (2013)
J. Lisman, R. Yasuda, S. Raghavachari. Mechanisms of postsynaptic CaMKII action in synaptic memory. Nat. Rev. Neurosci. 13:169-82 (2012)
H. Murakoshi, R. Yasuda. Postsynaptic signaling during plasticity of dendritic spines.Trends. Neurosci. 35: 135-43 (2012)
H. Murakoshi, H. Wang, R. Yasuda. Localized, persistent activation of Rho GTPases during long-term structural plasticity induced in single dendritic spines. Nature, 472:100-4 (2011)
R. Yasuda and H. Murakoshi. The mechanisms underlying the spatial spreading of signaling activity. Curr. Opin. Neurobiol. 21:313-21 (2011)
M. Patterson, R. Yasuda. Signaling pathways underlying structural plasticity of dendritic spines. Br. J. Pharmacol. 163: 1626-38 (2011)
M. A. Patterson, E. M. Szatmari, R. Yasuda. AMPA receptors are exocytosed in stimulated spines and adjacent dendrites in a Ras-ERK-dependent manner during long-term potentiation. Proc. Natl. Acad. Sci. U.S.A. 107: 15951-6 (2010)
M. C. Lee, R. Yasuda, M. D. Ehlers. Metaplasticity at single glutamatergic synapses.Neuron 66: 859-70 (2010)
S. B. Simmons, Y. Escobedo, R. Yasuda, S. M. Dudek. Regional differences in hippocampal calcium handling: a cellular mechanism for limiting plasticity. Proc. Natl. Acad. Sci. USA 106:14080-4 (2009)
S.-J. R. Lee, Y. Escobedo-Lozoya, E. M. Szatmari, R. Yasuda. Activation of CaMKII in single dendritic spines during long-term potentiation. Nature 458:299-304. (2009) (Article)
S.-J. R. Lee, R. Yasuda. Spatiotemporal regulation of signaling in and out of dendritic spines: CaMKII and Ras. Open Neurosci. J. 3:117-127 (2009)
H. Murakoshi, S.-J. Lee, and R. Yasuda. Highly sensitive and quantitative FRET-FLIM imaging in single dendritic spines using improved non-radiative YFP. Brain Cell Biol. 36:31-42 (2008)
C. D. Harvey†, R. Yasuda†, H. Zhong and K. Svoboda*. The spread of Ras activity triggered by activation of a single dendritic spine. Science 321:136-140 (2008)