Dr. Marcel Oberlaender
Max Planck Florida Institute
5353 Parkside Drive, Bldg. MC19-RE
Jupiter, FL 33458, USA
marcel.oberlaender at maxplanckflorida.org
Research Interests
Neuron and Network Anatomy
- 3D anatomy and synaptic wiring of thalamocortical and cortical circuits
- 3D distribution of neuron sub-types
Imaging and Image Processing Methods
- Development of large-scale fluorescent and bright field microscopy
- Method development for quantification of neuron and network anatomy
Computational Neuroscience
- Reconstruction/Simulation of anatomically realistic neuronal network models
- Sub-cellular mechanisms during thalamocortical activation of a cortical column
Publications
2011
- Kleinfeld D., Bharioke A., Blinder P., Bock D., Briggman K., Dmitri C., Denk W., Helmstaedter M., Kaufhold J., Lee W., Meyer H.S., Micheva K., Oberlaender M., Prohaska S., Reid R.C., Smith S., Takemura S., Tsai P., Sakmann, B.; Large-scale automated histology in the pursuit of connectomes. J Neurosci.
- Lang S., Dercksen V.J., Sakmann B., Oberlaender M.1; Simulation of signal flow in 3D reconstructions of an anatomically realistic neural network in rat vibrissal cortex. Neural Network.
- Boudewijns Z.S., Kleele T., Mansvelder H.D., Sakmann B., de Kock C.P., Oberlaender M.1.; Semi-automated three-dimensional reconstructions of individual neurons reveal cell type-specific circuits in cortex. Communicative & Integrative Biology.
- Oberlaender M.1., Boudewijns Z.S., Kleele T., Mansvelder H.D., Sakmann B., de Kock C.P.; Three-dimensional axon morphologies of individual layer 5 neurons indicate cell type-specific intracortical pathways for whisker motion and touch. Proc Natl Acad Sci U S A.
2010
- Dercksen V.J.2, Oberlaender M.2, Sakmann B., Hege H.-C.; Interactive Visualization as a Key Prerequisite for Reconstruction of Anatomically Realistic Neural Networks; In Proc on Visualization in Medical and Life Sciences (in press)
- Meyer, H.S., Wimmer, V.C., Oberlaender, M., de Kock, C.P., Sakmann, B., Helmstaedter, M.; Number and Laminar Distribution of Neurons in a Thalamocortical Projection Column of Rat Vibrissal Cortex. Cereb Cortex.
2009
- Oberlaender M., Three-dimensional reengineering of neuronal microcircuits – The cortical column in silico. Dissertation at the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany
- Dercksen V. J., Weber B., Günther D., Oberlaender M., Prohaska S., Hege H.-C.; Automatic alignment of stacks of filament data. In Proc. 2009 IEEE Int. Symp. on Biomedical Imaging: From Nano to Macro (ISBI), pages 971–974.
- Oberlaender M.12, Dercksen V.J.2, Egger R., Gensel M., Sakmann B., Hege H.-C.; Automated three-dimensional detection and counting of neuron somata. J Neurosci Methods
- Oberlaender M.1, Broser P.J., Sakmann B., Hippler S. Shack-Hartmann wavefront measurements in cortical tissue for deconvolution of large scale three-dimensional mosaic transmitted light brightfield micrographs. J Microsc.
2007
- Oberlaender M.1, Bruno R.M., Sakmann B., Broser P.J.; Transmitted light brightfield mosaic microscopy for three-dimensional tracing of single neuron morphology. J Biomed Opt.
2006
- Oberlaender M., High Resolution Transmitted Light Brightfield Mosaic Microscopy for Automatic Reconstrcution of Images of Neurons. Diploma thesis at to the Combined Faculties of Phsics and Astonomy of the Ruperto-Carola University of Heidelberg, Germany
1 Corresponding author. 2 Equal contribution.
Supervised Work
- Robert Egger, Physics Diploma (Master equivalent), 3D reconstruction and standardization of the barrel field in rat vibrissal cortex, (2011)
- Mike Hemberger, Neuroscience Master, Functional and anatomical charcterization of inhibitory neurons in the nucleus reticularis of mouse vibrissal thalamus, (2010)
- Rita Foerster, Biology Diploma (Master equivalent), 3D quantitative distribution of neurons in VPM of rat thalamus, (2009)