Samuel M. Young, Jr., PhD - Publications

1. Monica S. Montesinos, Zuxin Chen, and Samuel M. Young, Jr. pUNISHER: A high level expression cassette for use with recombinant viral vectors for rapid and long term in vivo neuronal expression in the CNS. J Neurophysiol. 106:3230-3244. (2011)
2. Dusonchet, J., Kochubey, O., Stafa K., Young, S.M. Jr., Zufferey, R., Moore, D.J., Schneider, B.L., Aebischer, P. A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2. J Neurosci. 31(3):907-12. (2011)
3. Kawabe, H., Neeb, A., Dimova, K., Young, S.M. Jr., Takeda, M., Katsurabayashi, S., Mitkovski, M., Malakhova, O.A., Zhang, D., Umikawa, M., Kariya, K., Goebbels, S., Nave, K., Rosenmund, C., Jahn, O., Rhee, J.S., and Brose, N. Regulation of Rap2A by Nedd4-1 Controls Dendrite Development in Cortical Neurons. Neuron. 65(3):358-72. (2010)
4. Young, S.M. Jr. and Neher, E. Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Neuron. 63(4):482-496. (2009)
5. Schikorski, T., Young, S.M. Jr., Hu, Y. Horseradish peroxidase cDNA as a marker for electron microscopy in neurons. J Neurosci Methods. 165(2):210-5. (2007)
6. Young, S.M. Jr. Proteolysis of SNARE proteins alters facilitation and depression in a specific way. PNAS. 102(7):2614-9. (2005)
7. McCarty, D.M., Young, S.M. Jr., and Samulski, R.J. Integration of Adeno-Associated Virus. (invited) Annu Rev Genet. 38:819-45. (2004)
8. Weitzman, M.D., Young, S.M. Jr., Cathomen, T., and Samulski, R.J. Targeted integration by adeno-associated virus. Methods Mol Med. 76201-19. (2003)
9. Young, S.M. Jr., and Samulski, R.J. Adeno-associated virus (AAV) site-specific recombination does not require a Rep-depedent origin of replication within the AAV terminal repeat. PNAS. 98(24), 13525-13530. (2001)
10. Young, S.M. Jr., McCarty, D.M., Natalya Degtyareva, and Samulski, R.J. Roles of Adeno-Associated Virus Rep Protein and Human Chromosome 19 in Site-Specific Recombination. Journal of Virology. 74(9)3953-3966. (2000)
11. Young, S.M. Jr., Xiao, W., and Samulski, R.J. Site specific targeting of DNA plasmids to chromosome 19 using AAV Cis and Trans sequences. Gene Targeting Vector Protocols Methods in Molecular Biology, Editor. E.B. Kmiec, Humana Press, Totowa, NJ, 2000. Methods in Molecular Biology. 133:111-26. (2000)
12. Gavin, D.K., Young, S.M. Jr., Xiao, W., Temple, B., Abernathy, C.R., Pereira, D.J., Muzyczka, N., and Samulski, R.J. Charge-to-Alanine Mutagenesis of the Adeno-Associated Virus Type 2 Rep 78/78 proteins yields temperature-sensitive and magnesium-dependent variants. Journal of Virology. 73(11)9433-9445. (1999)
13. Notterman, D., Young, S.M. Jr., Wainger, B., Levine, A.J. Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity. Oncogene. 17, 2743-2751. (1998)