Are presynaptic NMDA receptors postsynaptic?

Thursday, May 14th, 2015, 11:00 AM
Elmore Auditorium
Craig Jahr, PhD, Oregon Health & Science University
Jason Christie, PhD
(561) 972-9000

Event Information

A variety of consequences have been ascribed to the activation of NMDA receptors expressed on both the pre- and postsynaptic side of a variety of synapses.  The evidence for the expression of postsynaptic NMDA receptors is unequivocal; that for presynaptic receptors is in many cases less direct.  Though some findings are difficult to explain without positing the existence of presynaptic NMDA receptors, we find no evidence for their expression.  Of particular interest is the involvement of presynaptic NMDA receptors in the induction of spike-timing dependent long term depression in the cerebral cortex between layer 4 spiny stellate cells and layer 2/3 pyramidal cells.  Thus far, we suggest that the activation of postsynaptic NMDA receptors are required for this form of plasticity.


This seminar is open to faculty, scientists, and students from Max Planck Florida Institute for Neuroscience (MPFI), Florida Atlantic University (FAU), and the Scripps Research Institute Florida, located on FAU’s John D. MacArthur Campus in Jupiter, Florida. If you belong to an institution outside of the Jupiter campus and would like to attend, please send a request to