Creating New Input and Output Interfaces to the Brain with Fluorescent Proteins

Thursday, January 15th, 2015, 11:00 AM
Elmore Auditorium
Michael Z. Lin, MD, PhD
Ryohei Yasuda, PhD
(561) 972-9000

Event Information

The brain is a challenging organ to understand because its functions arise from electrical signals transiently passing through billions of neurons via trillions of synaptic connections, whose strengths change over time. Methods for visualizing electrical activity, biochemical changes, and structure in genetically defined neuronal subpopulations, and for manipulating the electrical and biochemical state of individual neurons, will be critical for unraveling this complexity. I will present new genetically encoded optical tools for sensing voltage with millisecond resolution and for visualizing late stages of synaptic plasticity occurring over hours. I will also present an uniquely generalizable method for reversibly controlling biochemical activities in the cell with light. Unexpectedly, all these methods use the same domain for either sensing or control, the fluorescent protein domain.

This seminar is open to faculty, scientists, and students from Max Planck Florida Institute for Neuroscience (MPFI), Florida Atlantic University (FAU), and the Scripps Research Institute Florida, located on FAU’s John D. MacArthur Campus in Jupiter, Florida. If you belong to an institution outside of the Jupiter campus and would like to attend, please send a request to seminars@mpfi.org