– Postdoc Candidate Seminar –
The local fast-spiking interneurons (FSINs) are considered to be crucial for the generation, maintenance and modulation of neuronal network oscillations especially in the gamma frequency band. Using whole cell current clamp patch recordings, we observed a sustained decrease of intrinsic excitability in the FSINs of the dentate gyrus (DG) following repetitive stimulations of the mossy fibers at 30 Hz (gamma bursts) which could not be expressed in the granule cells. Moreover, the study revealed that the FSIN membrane potential could modulate the expression of the plasticity. Using computational approach, we observed that altered intrinsic excitability in the FSINs could massively impact the network activities and the effect was dependent on the cause of the plasticity. Our study indicates that, FSINs which are known to be crucial for network oscillation generation can get affected by it which in turn can again modulate the oscillatory pattern.