Using Promoter-Restricted Transgenes to Assess Cellular, Regional, and Developmental Roles for Neurological Disease Genes

Monday, January 26th, 2015, 11:00 AM
Kahn Conf. Room 3010
Michael J. Yetman, Baylor College of Medicine - Postdoc Candidate
Hiroki Taniguchi, PhD
(561) 972-9000

Event Information

Transgenic mouse models of neurodegenerative disorders have yielded great insights into disease pathogenesis by recapitulating characteristic lesions and functional outcomes.  Despite early successes, interpretation of these studies is often confounded by the ubiquitous and exaggerated transgene expression required to recreate decades of human pathology in the mouse’s 2-year lifespan.  My research has utilized promoter-specified, conditional transgenic driver lines to limit expression of amyloid precursor protein (APP) containing familial mutations in a cellular, regional, and developmentally-specified manner to better understand how amyloid pathology contributes to cell death and cognitive decline in Alzheimer’s disease (AD).

This seminar is open to faculty, scientists, and students from Max Planck Florida Institute for Neuroscience (MPFI), Florida Atlantic University (FAU), and the Scripps Research Institute Florida, located on FAU’s John D. MacArthur Campus in Jupiter, Florida. If you belong to an institution outside of the Jupiter campus and would like to attend, please send a request to seminars@mpfi.org