- The Institute
- Postdoctoral Fellow
Department: Kwon Lab
Postdoctoral positions are available in the laboratory of Dr. Hyungbae Kwon. Our lab is currently located at the Max Planck Florida Institute, and the lab is moving to the Department of Neuroscience at Johns Hopkins University School of Medicine (http://neuroscience.jhu.edu/
) in the summer of 2019.
Essential Duties & Responsibilities
Our goal is to understand basic principles of neural circuit plasticity and how it influences cognitive brain functions and complex behaviors. The project will be performed by synapse, circuit, and behavior levels.
We have considerable expertise in the study of cellular mechanisms governing neural circuit development in which we mainly use electrophysiology and laser-based cutting-edge techniques such as two-photon imaging and photolysis of caged neurotransmitters (Kwon and Sabatini, Nature, 2011
; Kwon et al, Nature Neuroscience, 2012
; Oh et al, Science, 2016
In addition, our lab recently developed new optogenetic approaches (named iTango2 and Cal-Light) to label and control behaviorally-relevant neuronal circuits in behaving animals (Lee D et al, Nature Methods, 2017
; Lee D et al, Nature Biotechnology, 2017
). Using these tools, we plan to dissect circuit modules underlying complex cognitive behaviors and ultimately engineer or falsify memories of animals.
Several ongoing projects monitors neuronal activities in behaving animals by two-photon imaging, in vivo miniscope, electrophysiology, and fiber photometry. Together with all these cutting-edge imaging techniques, we are routinely dissect neuronal circuitry by viral tracing, optogenetic and chemogenetic manipulations, two-photon uncaging, and single cell/synapse resolution imaging with newly developed technology from our lab. In addition, several novel techniques that are useful for circuit dissections are currently under development.
Education and/or Experience
We are seeking for a candidate who wants to investigate neuronal circuits/learning principles underlying cognitive behaviors. The candidate should have a PhD or MD/PhD degree in neuroscience or related fields. A successful candidate is expected to use and combine all the tools that are listed above, especially Ca2+ imaging in freely behaving animals and data analysis of Ca2+ transients. Ability to decode neuronal activities into individual neuronal level is critical. In addition, optogenetic circuit manipulation should be routinely handled. A person who is interested in studying frontal part of brain including motor cortex, medial or orbital frontal cortex areas are encouraged to apply. A strong background in electrophysiology and/or optogenetics with related mouse genetics and viruses are preferred but not required.
A candidate who has a specialty in molecular biology, biochemistry, chemistry, physics, or engineering is also considered if the technique can be applied in neural circuit studies. Besides this position, we are also seeking a molecular biologist who has knowledge in light- and chemical- sensitive proteins and basic neural culture experiments.
Please send the CV, brief description of the previous work and future plan, and contact information of three references to Dr. Hyungbae Kwon at email@example.com