Dr. Shen (Ada) Tang joined the Yasuda’s lab as a postdoc in August 2012. Her research is to design and optimize fluorescent sensors in revealing protein kinase activity in dendritic spines during the structural plasticity induced by glutamate uncaging using two-photon fluorescence lifetime microscope with high spatiotemporal resolution.
Dr. Shen (Ada) Tang received her PhD in the Department of Chemistry at Georgia State University, specialized in Biochemistry, where she designed and applied genetically encoded fluorescent sensor to study Ca2+ signaling in endoplasmic/ sarcoplasmic reticulum by fluorescent microscope. In addition to measure Ca2+ dynamics in mammalian cells, the sensor has the capability the to quantitatively reveal fast sarcoplasmic reticulum (SR) Ca2+ depletion in adult mice skeletal muscle within millisecond resolution during physiologically relevant short-pulse voltage stimulation, enabling us to determine the molecular mechanism of diminished SR Ca2+ release in aging muscle. By collaboration, the high resolution X-ray structure of the sensor has been solved to reveal a hand-like metal binding site and elucidate the mechanism of Ca2+ induced fluorescence change.
- ERK activity in neurons during structural plasticity
- Mechanisms of structural LTP
- Two photon lifetime imaging and fluorescent sensor design
- PhD, Georgia State University, Department of Chemistry, Biochemistry (2012)
- BS, East China University of Science and Technology, Biotechnology (2006)