Dr. Andre Steinecke joined the Max Planck Florida Institute for Neuroscience as a Postdoc in November 2013 to study the cellular development of cortical Chandelier cells in mice. These interneurons originate in proliferative zones in the ventral embryonic brain and migrate over long distances to the cerebral cortex. Here they form specific axo-axonic connections with excitatory pyramidal cells. He investigates how these specific connections are formed during postnatal development by using cutting edge optical techniques in vivo and in vitro.
Before joining the Taniguchi Lab, Dr. Steinecke earned his PhD at the University of Jena, Germany at the lab of Dr. Jurgen Bolz. He studied extra- and intracellular factors that regulate the migration of cortical interneurons from their origin in the basal telencephalon to their destination in the cortex. He discovered that a specific interaction of guidance factors from the Ephrin family enhance the motility of these cells and that a Schizophrenia associated risk factor (DISC1) is necessary for the correct movement of these neurons.
- Development and circuit integration of cortical interneurons
- Subtype-specific function of cortical interneurons
- Experience-dependent development of cortical inhibitory circuits